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National Yang-Ming University

Cheng Huang

Associate Professor

 

Cheng Huang

 

 

 
 
 
Contact   Education

Phone(02)2826-7000 #5923(lab)

E-mail: chengh@ym.edu.tw

Ph.D., National Taiwan University

 

 

Awards

  1. Travel Award, The 12th Annual Meeting of Japanese Society of Medical Oncology, Fukuoka, Japan. (2014)
  2. TienTe Lee Award-Distinguished Thesis, TienTe Lee Biomedical Foundation, Taiwan (2009)
  3. Travel Award, International Meeting on the Molecular Biology of Hepatitis B Viruses, San Diego, USA (2008)
  4. Best poster award, Symposium on Frontier Biomedical Sciences, Taiwan (2008)
  5. Outstanding Graduate Student Research Award, The National Taiwan University College of Medicine (2008)
  6. Best poster award, The 14th East Asia Joint Symposium, Japan (2007)
  7. Outstanding Students Conference Travel Grant, the Foundation for the Advancement of Outstanding Scholarship (FAOS), Taiwan (2006)

 

Research Interest
  1. Hepatitis B virus (HBV) causes acute and chronic infections in humans; such infections are often associated with severe liver diseases, including cirrhosis and hepatocellular carcinoma (HCC). Hepatitis delta virus (HDV) causes fulminant hepatitis and progressive chronic liver cirrhosis in patients superinfected or coinfected with HBV. We examined the roles of clathrin-mediated trafficking pathway involved in the life cycle of HBV/HDV. In addition, the receptor on the plasma membrane which is required for the infection of HBV/HDV is NTCP. We have established HBV/HDV infection model in vitro and in vivo. Our model will help us to develop new drugs for treatment of HBV/HDV infection. Our study suggests new strategies for manipulating HBV/HDV for therapeutic purposes in treating disorders associated with liver injury and cirrhosis.
  2. Obesity and dysregulated insulin action in the liver are strongly associated and are currently a worldwide health problem. Fatty liver, the initial stage of nonalcoholic fatty liver disease (NAFLD), is a common metabolic symptom, and is caused by an imbalance of lipid metabolism. The purpose of our proposal is to develop drugs for metabolic syndrome.  We will design a process of pharmacology experiments for development of new functional food or new drugs. In addition, we will complete additional safety evaluation for new functional food or new drugs.

Representative Publications

  1. Hao Chiang, Jinq-Chyi Lee, Hsiu-Chen Huang, Hsing Huang, Hui-Kang Liu, and Cheng Huang*. (2019) Delayed intervention with a novel SGLT2 inhibitor NGI001 suppresses diet-induced metabolic dysfunction and nonalcoholic fatty liver disease in mice. British Journal of Pharmacology. [Accepted] (* Corresponding author) (IF=6.583; Pharmacology & pharmacy, 14/267=5.2%)

  2. Hsu-Feng Lu, Yu-Heng Lai, Hsiu-Chen Huang, I-Jung Lee, Lie-Chwen Lin, Hui-Kang Liu, Hsiao-Hsuan Tien, and Cheng Huang*. (2019) Ginseng-plus-Bai-Hu-Tang ameliorates diet-induced obesity, hepatic steatosis and insulin resistance in mice. Journal of Ginseng Research. [Accepted] (* Corresponding author) (IF=4.029; Integrative & complementary medicine, 2/27=7.4%)

  3. Ting-Chen Chang, Hao Chiang, Yu-Heng Lai, Yu-Ling Huang, Hsiu-Chen Huang, Yu-Chih Liang, Hui-Kang Liu,  and Cheng Huang*. (2019) Helminthostachys zeylanica alleviates hepatic steatosis and insulin resistance in diet-induced obese mice. BMC Complementary and Alternative Medicine. 19:368 (* Corresponding author) (IF=2.479; Integrative & complementary medicine, 8/27=29.6%)

  4. Ming-Ju Hsieh, Cheng Huang*, Chia-Chieh Lin, Chih-Hsin Tang, Chih-Yang Lin, I-Neng Lee, Hsiu-Chen Huang, and Jui-Chieh Chen. (2019) Basic fibroblast growth factor promotes doxorubicin resistance in chondrosarcoma cells by affecting XRCC5 expression. Molecular Carcinogenesis. [Accepted] (*Co-first author) (IF=3.411; Biochemistry & Molecular Biology, 119/299=39.8%)

  5. Ming‑Ju Hsieh, Yin‑Hong Chen, I‑Neng Lee, Cheng Huang, Yu‑Ju Ku and Jui‑Chieh Chen. (2019) Secreted amphiregulin promotes vincristine resistance in oral squamous cell carcinoma. International Journal of Oncology. 55: 949-959

  6. Jui-Chieh Chen, I-Neng Lee, Cheng Huang, Yu-Ping Wu, Chiu-Yen Chung, Ming-Hsueh Lee, Martin Hsiu-Chu Lin, Jen-Tsung Yang. (2019) Valproic acid-induced amphiregulin secretion confers resistance to temozolomide treatment in human glioma cells. BMC Cancer. 19(1):756-760

  7. Lie-Chwen Lin, Lin-Chien Lee, Cheng Huang, Chiung-Tong Chen, Jen-Shin Song, Young-Ji Shiao, Hui-Kang Liu. (2019) Effects of Boschnaloside from Boschniakia rossica on dysglycemia and islet dysfunction in severely diabetic mice through modulating the action of glucagon-like peptide-1. Phytomedicine. 62:152946

  8. Cheng Huang, Yu-Ling Huang, Chia-Chi Wang, Yi-Ling Pan, Yu-Heng Lai, and Hsiu-Chen Huang. (2019) Ampelopsin A and ampelopsin C induce apoptosis and metastasis through down-regulating AxL, TYRO3, and FYN expressions in MDA-MB-231 breast cancer cells. Journal of Agricultural and Food Chemistry. 67(10):2818-2830 (First author) (IF=3.571; Agriculture, multidisciplinary, 3/56=5.4%)

  9. Yen-Chang Lin, Cheng Huang*, Hsiu-Chen Huang, Ming-Ting Liao, Yu-HengLai. (2019) Metabolomics profiling of haloperidol and validation of thromboxane-related signaling in the early development of zebrafish.  Biochem Biophys Res Commun. pii: S0006-291X(19)30625-4 (* Co-first author) (IF=2.705; Biophysics, 28/72=38.9%)

  10. Yu-Chun Lin, Cheng Huang, Hsin-Chih Lai. (2019) Revealing the ultrastructure of the membrane pores of intact Serratia marcescens cells by atomic force microscopy. Heliyon. 5:e02636

  11. Jui-Chieh Chen, Cheng Huang, I-Neng Lee, Yu-Ping Wu, Chih-Hsin Tang. (2018) Amphiregulin enhances cell migration and resistance to doxorubicin in chondrosarcoma cells through the MAPK pathway. Molecular Carcinogenesis. 57(12):1816-1824

  12. Han-Min Chen, Lin-Chien Lee, Kuang-Yu Hu, Wei-Jern Tsai, Cheng Huang, Hui-Jen Tsay, Hui-Kang Liu. (2018) The Application of Post-Translational Modification Oriented Serum Proteomics to Assess Experimental Diabetes with Complications. PLOS ONE. 13(11):e0206509

  13. Yu-Heng Lai, Cheng-Pu Sun, Hsiu-Chen Huang, Jui-Chieh Chen, Hui-Kang Liu and Cheng Huang*. (2018) Epigallocatechin gallate inhibits hepatitis B virus infection in human liver chimeric. BMC Complementary and Alternative Medicine. 18:248-254 (* Corresponding author) (IF=2.479; Integrative & complementary medicine, 8/27=29.6%)

  14. Liu GT, Kung HN, Chen CK, Huang C, Wang YL, Yu CP, Lee CP. (2018) Improving nuclear envelope dynamics by EBV BFRF1 facilitates intranuclear component clearance through autophagy. FASEB Journal. 32(7):3968-3983 

  15. Hsiu-Chen Huang, Hsu-Feng Lu, Yu-Heng Lai, Chung-Pei Lee, Hui-Kang Liu, and Cheng Huang*. (2017) Tat-enhanced delivery of the C terminus of HDAg-L inhibits assembly and secretion of hepatitis D virus. Antiviral Research. 150:69-78 (* Corresponding author) (IF=4.130; Pharmacology & pharmacy, 50/267=18.7%)

  16. Huang HC, Lee CP, Liu HK, Chang MF, Lai YH, Lee YC, Huang C*. (2016) Cellular Nuclear Export Factors TAP and Aly Are Required for HDAg-L-mediated Assembly of Hepatitis Delta Virus. Journal of Biological Chemistry. 291(50):26226-26238. (* Corresponding author) (IF=4.106; Biochemistry & molecular biology, 81/298=27.2%)

  17. Tseng TS, Chuang SM, Hsiao NW, Chen YW, Lee YC, Lin CC, Huang C, Tsai KC. (2016) Discovery of a potent cyclooxygenase-2 inhibitor, S4, through docking-based pharmacophore screening, in vivo and in vitro estimations. Molecular Biosystems. 12(8):2541-51. doi: 10.1039/c6mb00229c.

  18. Huang C, Wei YX, Shen MC, Tu YH, Wang CC, Huang HC. (2016) Chrysin, Abundant in Morinda citrifolia Fruit Water-EtOAc Extracts, Combined with Apigenin Synergistically Induced Apoptosis and Inhibited Migration in Human Breast and Liver Cancer Cells. Journal of Agricultural and Food Chemistry. 64:4235-45 (First author) (IF=3.571; Agriculture, multidisciplinary, 3/56=5.4%)

  19. Cheng Huang*, Chung-Kuang Lu, Ming-Chin Tu, Jia-Hua Chang, Yen-Ju Chen, Yu-Hsuan Tu, and Hsiu Chen Huang. (2016) Polyphenol-rich Avicennia marina leaf extracts induce apoptosis in human breast and liver cancer cells and in a nude mouse xenograft model. Oncotarget. 7(24):35874-35893. doi: 10.18632/oncotarget.8624. (* First author)

  20. Hui-Kang Liu, Tzu-Min Hung, Hsiu-Chen Huang, I-Jung Lee, Chia-Chuan Chang, Jing-Jy Cheng, Lie-Chwen Lin, and Cheng Huang*. (2015) Bai-Hu-Jia-Ren-Shen-Tang Decoction Reduces Fatty Liver by Activating AMP-activated Protein Kinase In Vitro and In Vivo. Evidence-Based Complementary and Alternative Medicine. doi:10.1155/2015/651734  (* Corresponding author) (IF=1.984; Integrative & complementary medicine, 10/27=37.0%)

  21. Cheng Huang*, Yi-Jing Chen, Wei-Jen Chen, Chih-Li Lin, Yu-Xuan Wei, and Hsiu-Chen Huang. (2015) Combined treatment with chrysin and 1,2,3,4,6-penta-O-galloyl-β-D-glucose synergistically inhibits LRP6 and Skp2 activation in triple-negative breast cancer and xenografts. Molecular carcinogenesis. 54:1613-25 (* First author) (IF=3.411; Biochemistry & Molecular biology, 119/298=39.9%)

  22. Hsiu-Chen Huang, Mi-Hua Tao, Tzu-Min Hung, Jui-Chieh Chen, Zi-Jun Lin, Cheng Huang*. 2014(-)-Epigallocatechin-3-gallate Inhibits Entry of Hepatitis B Virus into Hepatocytes. Antiviral Research. 111:100-111 (* Corresponding author) (IF=4.130; Pharmacology & pharmacy, 50/267=18.7%)

  23. Sheng-Fan Wang, Yueh-Ching Chou, Nirmal Mazumder, Fu-Jen Kao, Leslie D. Nagy, F. Peter Guengerich, Cheng Huang, Hsin-Chen Lee, Ping-Shan Lai, Yune-Fang Ueng. (2013) 7-Ketocholesterol induces P-glycoprotein through PI3K/mTOR signaling in hepatoma cells. Biochemical Pharmacology 86(4):548-60. 

  24. Huang C*, Lee SY, Lin CL, Tu TH, Chen LH, Chen YJ, and Huang HC. (2013) Co-treatment with Quercetin and 1,2,3,4,6-Penta-O-galloyl-β-d-glucose Causes Cell Cycle Arrest and Apoptosis in Human Breast Cancer MDA-MB-231 and AU565 Cells. Journal of Agricultural and Food Chemistry 61: 6430−6445 (* First author) (IF=3.571; Agriculture, multidisciplinary, 3/56=5.4%)

  25. Cheng Huang*, Jia-Yin Jiang, Shin C. Chang, Yeou-Guang Tsay, Mei-Ru Chen, and Ming-Fu Chang. (2013) NESI Protein Forms Complexes with Lamin A/C-Nups to Mediate the CRM1-Independent Nuclear Export of Large Hepatitis Delta Antigen. Journal of Virology. 87:1596-604 (* First author) (IF=4.324; Virology, 8/36=22.2%)

  26. Pei-Yun Chuang, Cheng Huang, and Hsiu-Chen Huang. (2013) The use of a combination of tamoxifen and doxorubicin synergistically to induce cell cycle arrest in BT483 cells by down-regulating CDK1, CDK2 and cyclin D expression. Journal of Pharmaceutical Technology & Drug Research 2: 1-4

  27. Hsiu-Chen Huang, Chun-Chi Chen, Wen-Cheng Chang, Mi-Hua Tao, and Cheng Huang*. (2012) Entry of Hepatitis B Virus into Immortalized Human Primary Hepatocytes by Clathrin-Dependent Endocytosis. Journal of Virology. 86:9443-9453 (* Corresponding author) (IF=4.324; Virology, 8/36=22.2%)

  28. Shih-Han Sun, Hsiu-Chen Huang, Cheng Huang, Jen-Kun Lin. (2012) Cycle arrest and apoptosis in MDA-MB-231/Her2 cells induced by curcumin. European Journal of Pharmacology. 690:22-30 

  29. Cheng Huang*, Shin C. Chang, Hui-Chin Yang, Chung-Liang Chien, and Ming-Fu Chang (2009) Clathrin-mediated post-Golgi trafficking in the morphogenesis of hepatitis delta virus. Journal of Virology. 83:12314-12324 (* First author) (IF=4.324; Virology, 8/36=22.2%)

  30. Tzu-Min Hung, Shin C. Chang, Wei-Hsuan Yu, Yu-Wen Wang, Cheng Huang, Shao-Chun Lu, Po-Huang Lee, and Ming-Fu Chang (2009) A novel nonsynonymous variant of matrix metalloproteinase-7 confers risk of liver cirrhosis. Hepatology. 50:1184-1193

  31. Cheng Huang*, Shin C. Chang, I-Chen Yu, Yeou-Guang Tsay, and Ming-Fu Chang (2007) Large hepatitis delta antigen is a novel clathrin adaptor-like protein. Journal of Virology. 81:5985-5994. A Highlights from JV Selection. (* First author) (IF=4.324; Virology, 8/36=22.2%)

  32. Yun-Hsin Wang, Shin C. Chang, Cheng Huang, Ya-Ping Li, Chia-Huei Lee, and Ming-Fu Chang. (2005) Novel nuclear export signal interacting protein, NESI, critical for the assembly of hepatitis delta virus. Journal of Virology. 79:8113-8120 

Patent
  1. 劉慧康,林麗純,李文泰,黃琤,蔡耿彰/ 具有GLP-1受體調控活性之化合物及其用途/ 發明第I 511963/ 中華民國專利 (2015)

  2. 劉慧康,林麗純,李文泰,黃琤,蔡耿彰/ 具有GLP-1受體調控活性之化合物及其用途/ ZL 2014 1 0584351.1/ 中國大陸專利 (2017)

  3. 黃琤,蔡耿彰,黃鈺玲,董明兆,黃琇珍,陳旺全/ 錫蘭七指蕨、入地蜈蚣素及黃酮類化合物用於治療或預防新陳代謝疾病之用途/ 發明第I 621440/中華民國專利 (2018)

  4. 黃琤,蔡耿彰,黃鈺玲,董明兆,黃琇珍,陳旺全,劉慧康/ 錫蘭七指蕨、入地蜈蚣素及黃酮類化合物用於治療或預防新陳代謝疾病之用途/ I1025-0004-US/ 美國專利 (2019)