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National Yang-Ming University

Tsuey-Ching Yang

 Professor

 

   

 

Tsuey-Ching Yang

 

 

 
 
 
Contact   Education

Office: Research Building Room 311

Phone(02)2826-7289(office)       (02)2826-7000 #5864(lab)

E-mail: tcyang@ym.edu.tw

 

 

Ph.D., National Chung-Hsing University

M.S., National Taiwan University

B.S., National Taiwan University

 

 

 

Research Interest
  1. Prevalence and mechanisms of antibiotic resistance of Stenotrophomonas maltophilia
  2. Stresses adaption response of Stenotrophomonas maltophilia

 

Representative Publications

  1. Yi-Wei Huang, Hsin-Hui Huang, Kai-Hung Huang, Wei-Chien Chen, Yi-Tsung Lin, Cheng-Chih Hsu, and Tsuey-Ching Yang* (2019) AmpI functions as an iron exporter to alleviate b-lactam-mediated ROS stress in Stenotrophomonas maltophilia. Antimicrobial Agents and Chemotherapy. 63:e02467-18. (Corresponding author)
  2. Hsin-Hui Huang, Peng-Ying Chen, Rouh-Mei Hu, Yi-Tsung Lin, Li-Hua Li, Tsuey-Ching Yang*. (2018) The impacts of L1 promoter variation and L2 clavulanate susceptibility on ticarcillin-clavulanate susceptibility of Stenotrophomonas maltophilia. Antimicrobial Agents and Chemotherapy. 62:e01222-18. (Corresponding author)
  3. Hsin-Hui Huang, Yi-Tsung Lin, Peng-Ying Chen, Li-Hua Li, Hsiao-Chen Ning, Tsuey-Ching Yang*. (2018) ClpA and HtpX proteases are involved in intrinsic aminoglycoside resistance of Stenotrophomonas maltophilia and are potential aminoglycoside adjuvant targets. Antimicrobial Agents and Chemotherapy. 62: e00554-18. (Corresponding author)
  4. Chao-Jung Wu, Tsu-Ting Chiu, Yi-Tsung Lin, Yi-Wei Huang, Li-Hua Li, Tsuey-Ching Yang*. (2018) Role of smeU1VWU2X operon in the alleviation of oxidative stresses and the occurrence of sulfamethoxazole/trimethoprim-resistant mutants in Stenotrophomonas maltophilia. Antimicrobial Agents and Chemotherapy 62:e02114-17. (Corresponding author)
  5. Ying-Hsiu Lin, Tsuey-Ching Yang*, Wensi S. Hu*. (2018) Characterization of stm3030 and stm3031 genes of Salmonella enterica serovar Typhimurium in relation to cephalosporin resistance. Journal of Microbiology, Immunology, and Infection. pii: S1684-1182(18)30413-4. (Corresponding author)
  6. Yi-Tsung Lin*, Yi-Hsiang Cheng, Chih-Han Juan, Ping-Feng Wu, Yi-Wei Huang, Sheng-Hua Chou, Tsuey-Ching Yang, Fu-Der Wang. (2018) High mortality among patients infected with hypervirulent antimicrobial-resistant capsular type K1 Klebsiella pneumoniae strains in Taiwan. International Journal of Antimicrobials Agents. 52:251-257.
  7. Yen-Hua Huaang, Sheng-Hua Chou, Syun-Wun Liang, Chung-En Ni, Yi-Tsung Lin*, Yi-Wei Huang, Tsucy-Ching Yang. (2018) Emergence of an XDR and carbapenemase-producing hypervirulent Klebsiella pneumoniae strain in Taiwan. Journal of Antimicrobial Chemotherapy. 73:2039-2046.
  8. Ping-Feng Wu, Yi-Tsung Lin*, Fu-Der Wang, Tsuey-Ching Yang, Chang-phone Fung. (2018) Is fluoroquinolone monotherapy a useful alternative treatment for Pseudomonas aeruginosa bacteraemia? Infection. 46:365-373.
  9. Yi-Wei Huang, Yu Wang, Yun Lin, Chin Lin, Yi-Tsung Lin, Cheng-Chih Hsu*, Tsuey-Ching Yang*. (2017) Impacts of penicillin binding protein 2 inactivation on b-lactamase expression and muropeptide profile in Stenotrophomonas maltophilia. mSystems. 2:e00077-17. (Corresponding author)
  10. Yi-Wei Huang, Cheng-Wen Lin, Hsiao-Chen Ning, Yi-Tsung Lin, Yi-Chih Chang, Tsuey-Ching Yang*. (2017) Overexpression of SmeDEF efflux pump decreases aminoglycoside resistance in Stenotrophomonas maltophilia. Antimicrobial Agents and Chemotherapy 61:e02685-16. (Corresponding author)
  11. Hsin-Hui Huang, Wei-Ching Chen, Cheng-Wen Lin, Yi-Tsung Lin, Hsiao-Chen Ning, Yi-Chih Chang, Tsuey-Ching Yang*. (2017) Relationship of the CreBC two-component regulatory system and inner membrane protein CreD with swimming motility in Stenotrophomonas maltophilia. PLoS One 12:e0174707. (Corresponding author)
  12. Chao-Jung Wu, Yi-Wei Huang, Yi-Tsung Lin, Tsuey-Ching Yang*. (2016) Inactivation of lytic transglycosylases increases susceptibility to aminoglycosides and macrolides by altering the outer membrane permeability of Stenotrophomonas maltophilia. Antimicrobial Agents and Chemotherapy 60:3236-3239. (Corresponding author)
  13.  Chao-Jung Wu, Yi-Wei Huang, Yi-Tsung Lin, Hsiao-Chen Ning, Tsuey-Ching Yang*. (2016) Inactivation of SmeSyRy two-component regulatory System inversely regulates the expression of SmeYZ and SmeDEF efflux pumps in Stenotrophomonas maltophilia. PLoS One 11:e0160943. (Corresponding author)
  14. Shih-Wein Lin, Ching-Ying Yang, Yu-Jen Jou, Tsuey-Ching Yang, Su-Hua Huang, Lei Wan, Ying-Ju Lin, Cheng-Wen Lin. (2016) SARS coronavirus papain-like protease induces Egr-1-dependent up-regulation of TGF-β1 via ROS/p38 MAPK/STAT3 pathway. Scientific Reports 13;6:25754.
  15. Chih-Han Juan, Yi-Wei Huang, Yi-Tsung Lin, Tsuey-Ching Yang, Fu-Der Wang. (2016) Risk factors, outcomes, and mechanisms of tigecycline-nonsusceptible Klebsiella pneumoniae bacteremia. Antimicrobial Agents and Chemotherapy 60:7357-7363.
  16. Yi-Tsung Lin, Yi-Wei Huang, Hsin-Hui Huang, Tsuey-Ching Yang, Fu-Der Wang, Chang-Fung Fung. (2016) In vivo evolution of tigecycline-non-susceptible Klebsiella pneumoniae strains in patients: relationship between virulence and resistance. International Journal of Antimicrobial Agents 48:485-491.
  17. Yi-Wei Huang, Chao-Jung Wu, Rouh-Mei Hu, Yi-Tsung Lin, Tsuey-Ching Yang*. (2015) Interplay among membrane-bound lytic transglycosylase D1, the CreBC two-component regulatory system, the AmpNG-AmpDI-NagZ-AmpR regulatory circuit, and L1/L2 beta-lactamase expression in Stenotrophomonas maltophilia. Antimicrobial Agents and Chemotherapy 59:6866-6872. (Corresponding author)
  18. Yi-Tsung Lin, Yi-Wei Huang, Shiang-Jiuun Chen, Chia-Wei Chang, Tsuey-Ching Yang*. (2015) The SmeYZ efflux pump of Stenotrophomonas maltophilia contributes to drug resistance, virulence-related characteristics, and virulence in mice. Antimicrobial Agents and Chemotherapy 59:4067-4073. (Corresponding author)
  19. Hsin-Hui Huang, Yi-Tsung Lin, Wei-Ching Chen, Yi-Wei Huang, Shiang-Jiuun Chen, Tsuey-Ching Yang*. (2015) Expression and functions of CreD, an inner membrane protein in Stenotrophomonas maltophilia. PLoS One 10:e0145009. (Corresponding author)
  20. Yi-Wei Huang, Rouh-Mei Hu, Yi-Tsung Lin, Hsin-Hui Huang, Tsuey-Ching Yang*. (2015) The contribution of class 1 integron to antimicrobial resistance in Stenotrophomonas maltophilia. Microbial Drug Resistance 21:90-96. (Corresponding author)
  21. Yi-Wei Huang, Rung-Shiuan Liou, Yi-Tsung Lin, Hsin-Hui Huang, Tsuey-Ching Yang*. (2014) A linkage between SmeIJK efflux pump, cell envelope integrity, and sigma s-mediated envelope stress response in Stenotrophomonas maltophilia. PLoS One 9:e111784. (Corresponding author)
  22. Yi-Tsung Lin, Yi-Wei Huang, Rung-ShiuanLiou, Yi-Chih Chang, Tsuey-Ching Yang*. (2014) MacABCsm, an ABC-type tripartite efflux pump of Stenotrophomonas maltophilia involved in drug resistance, oxidative and envelope stress tolerances and biofilm formation. Journal of Antimicrobial Chemotherapy 69:3221-3226. (Corresponding author)
  23. Cheng-Wen Lin, Yi-Wei Huang, Rouh-Mei Hu, Tsuey-Ching Yang*. (2014) SmeOP-TolCsm efflux pump contributes to multidrug resistance of Stenotrophomonas maltophilia. Antimicrobial Agents and Chemotherapy 58:2405-2408. (Corresponding author)
  24. Shih-Wen Li, Tsuey-Ching Yang, Chien-Chen Lai, Su-Hua Huang, Jun-Ming Liao, Lei Wan, Ying-Ju Lin, Cheng-Wei Lin. (2014) Antiviral activity of aloe-emodin against influenza A virus via galectin-3 up-regulation. European Journal of Pharmacology 738:125-132.
  25. Tsuey-Ching Yang, Tzu-Fan Chen, Jeffrey J. P. Tsai, Rouh-Mei Hu. (2014) NagZ is required for beta-lactamase expression and full pathogenicity in Xanthomonas campestris pv. campestris str 17. Research in Microbiology 165:612-619. (First author)
  26. Yi-Wei Huang, Rouh-Mei Hu, Fang-Yeh Chu, Hui-Rung Lin, Tsuey-Ching Yang*. (2013) Characterization of a major facilitator superfamily (MFS) tripartite efflux pump EmrCABsm from Stenotrophomonas maltophilia. Journal of Antimicrobial Chemotherapy 68: 2498-2505. (Corresponding author)
  27. Yi-Wei Huang, Rouh-Mei Hu, Tsuey-Ching Yang*. (2013) Role of the pcm-tolCsm operon in the multidrug resistance of Stenotrophomonas maltophilia. Journal of Antimicrobial Chemotherapy 68: 1987-1993. (Corresponding author)
  28. Tsuey-Ching Yang, Shih-Wein Li, Chien-Chen Lai, Kai-Zen Lu, Man-Tzu Chiu, Tsung-Ham Hsieh, Lei Wan, Cheng-Wen Lin*. (2013) Proteomic analysis for Type I interferon antagonism of Japanese encephalitis virus NS5 protein. Proteomics 13:3442-3456. (First author)
  29. Tsuey-Ching Yang, Tzu-Fan Chen, Jeffrey J. P. Tsai, Rouh-Mei Hu. (2013) AmpG is required for BlaXc beta-lactamase expression in Xanthomonas campestris pv. campestris str. 17. FEMS Microbiology Letters 340:101-108. (First author)
  30. Rouh-Mei Hu, Sih-Ting Liao, Chiang-Ching Huang, Yi-Wei Huang, Tsuey-Ching Yang*. (2012) An inducible fusaric acid tripartite efflux pump contributes to the fusaric acid resistance in Stenotrophomonas maltophilia. PLoS One 7:e51053. (Corresponding author)
  31. Yi-Wei Huang, Rouh-Mei Hu, Cheng-Wen Lin, Tung-Ching Chung, Tsuey-Ching Yang*. (2012) NagZ-dependent and NagZ-independent mechanisms for the b-lactamases expression in Stenotrophomonas maltophilia. Antimicrobial Agents and Chemotherapy 56:1936-1941. (Corresponding author)
  32. Shih-Wen Li, Tsuey-Ching Yang, Lei Wan, Ying-Ju Lin, Fuu-Jen Tsai, Chien-Chen Lai, Cheng-Wen Lin*. (2012) Correlation between TGF-b1 expression and proteomic profiling induced by severe acute respiratory syndrome coronavirus papain-like protease. Proteomics 12:3193-3205.
  33. Tsuey-Ching Yang, David Hecht, Jeffrey J. P. Tsai, Rouh-Mei Hu*. (2012) Cefoxitin is both an inhibitor of class A beta-lactamase of Xanthomonas cempestris pv. campestris str. 17 and an inducer of its gene. Research in Microbiology 163:550-556. (First author)
  34. Chao-Hsien Chen, Chiang-Ching Huang, Tsao-Chuen Chung, Rouh-Mei Hu, Yi-Wei Huang, Tsuey-Ching Yang*. (2011) Contribution of resistance-nodulation-division efflux pump operon smeU1-V-W-U2-X to multidrug resistance of Stenotrophomonas maltophilia. Antimicrobial Agents and Chemotherapy 55:5826-5833. (Corresponding author)
  35. Cheng-Wen Lin, Hsin-Chieh Lin, Yi-Wei Huang, Tung-Ching Chung, Tsuey-Ching Yang*. (2011) Inactivation of mrcA gene derepresses the basal-level expression of L1 and L2 beta-lactamases in Stenotrophomonas maltophilia. Journal of Antimicrobial Chemotherapy 66:2033-2037. (Corresponding author)
  36. Yi-Chin Chang, Mei-Jung Tsai, Yi-Wei Huang, Tung-Ching Chung, Tsuey-Ching Yang*. (2011) SmQnrR, a DeoR-type transcriptional regulator, negatively regulates the expression of Smqnr and SmtcrA in Stenotrophomonas maltophilia. Journal of Antimicrobial Chemotherapy 66:1024-1028. (Corresponding author)
  37. Tsuey-Ching Yang, Me-Jung Tsai, Jeffrey, J. P. Tsai, Rouh-Mei Hu*. (2011) Induction of a secretable beta-lactamase requires a long lag time in Xanthomonas campestris pv. Campestris str. 17. Research in Microbiology 162:999-1005. (First author)
  38. Yi-Wei Huang, Rouh-Mei Hu, Yu-Ting Chiang, Tsao-Chuen Chung, Tung-Ching Chung, Tsuey-Ching Yang*. (2011) Establishment of an arabinose-inducible system in Stenotrophomonas maltophilia. Folia Microbiologica 56:18-22. (Corresponding author)
  39. Yi-Wei Huang, Cheng-Wen Lin, Rouh-Mei Hu, Yu-Tzu Lin, Tung-Ching Chung, Tsuey-Ching Yang*. (2010) An AmpN-AmpG operon is essential for the expression of L1 and L2 beta-lactamases in Stenotrophomonas maltophilia. Antimicrobial Agents and Chemotherapy 54:2583-2589. (Corresponding author)
  40. Yi-Chih Chang, Yi-Wei Huang, Kai-Hung Chiang, Tsuey-Ching Yang*, Tung-Ching Chung*. (2010) Introduction of an AmpR-L2 intergenic segment attenuates the induced beta-lactamase activity of Stenotrophomonas maltophilia. European Journal of Clinical Microbiology and Infectious Disease 29:887-890. (Corresponding author)
  41.  Tsuey-Ching Yang, Chien-Chen Lai, Su-LianShiu, Pei-Hsin Chuang, Bo-Cheng Tzou, Ying-Ya Lin, Fuu-Jen Tsai, Cheng-Wen Lin*. (2010) Japanese encephalitis virus down-regulates thioredoxin and induces ROS-mediated ASK1-ERK/p38MAPK activation in human promonocyte cells. Microbes and Infection 12:643-651. (First author)
  42. Ping-Ning Hsu*, Tsuey-Ching Yang*, Jung-Ta Kao, Ken-Sheng Cheng, Yi-Ju Lee, Yuan-Min Wang, Chin-Tung Hsieh, Cheng-Wen Lin, Yi-Ying Wu*. (2010) Increased PD-1 and decreased CD28 expression in chronic hepatitis B patients with advanced hepatocellular carcinoma. Liver International 30:1379-1386. (Corresponding author)
  43. Nai-Wan Hsiao, Jiun-Wei Chen, Tsuey-Ching Yang, Gregg M. Orloff, Yi-Ying Wu, Chih-Ho Lai, Yu-Ching Lan, Cheng-Wen Lin*. (2010) ISG15 over-expression inhibits the replication of Japanese encephalitis virus in human medulloblastoma cells. Antiviral Research 85:504-511.
  44. Tsuey-Ching Yang*, Yi-Wei Huang, Rouh-Mei Hu, Shao-Cheng Huang, and Yu-Tzu Lin. (2009) AmpDI is involved in expression of chromosomal L1 and L2 b-lactamases of Stenotrophomonas maltophilia. Antimicrobial Agents and Chemotherapy 53:2902-2907. (Corresponding author)
  45. Tsuey-Ching Yang, Yu-Wei Leu, Hui-Chen Chang-Chien, Rouh-Medi Hu*. (2009) Flagellar biogenesis of Xanthomonas campestris requires alternative sigma factors RpoN2 and FliA, and temporally regulated by FlhA, FlhB and FlgM. Journal of Bacteriology 191:2266-2275. (First author)
  46. Cheng-Wen Lin, Yi-Wei Huang, Rouh-Mei Hu, Kai-Hung Chiang, Tsuey-ChingYang*. (2009) The role of AmpR in the regulation of L1 and L2 beta-lactamases in Stenotrophomonas maltophilia. Research in Microbiology 160:152-158. (Corresponding author)
  47. Rouh-Mei Hu, Kai-Hung Chiang, Yi-Chih Chang, Tsuey-Ching Yang*. (2009) Characterization of the charge variants of L2 beta-lactamase in Stenotrophomonas maltophilia. Journal of Medical Microbiology 58:318-321. (Corresponding author)
  48. Tsuey-Ching Yang, Chun-Pin Chang, Yu-Ching Lan, Chao-Li Liu, Mu-Chin Shih, Fang-Yang Wu, Cheng-Wen Lin. (2009) Recombinant ORF66 and ORFK12 antigens for the detection of human herpesvirus 8 antibodies in HIV-positive and –negative patients. Biotechnology Letters 31:629-637. (First author)
  49. Tsuey-Ching Yang, Su-Lian Shiu, Pei-Hsin Chuang, Ying-Ju Lin, Lei Wan,Yu-Ching Lan, Cheng-Wen Lin*. (2009) Japanese encephalitis virus NS2B-NS3 protease induces caspase 3 activation and mitochondria-mediated apoptosis in human medulloblastoma cells. Virus Research 143:77-85. (First author)
  50. Rouh-Mei Hu, Kuang-Jay Huang, Lii-Tzu Wu, Ying-Ju Hsiao, Tsuey-Ching Yang*. (2008) Induction of L1 and L2 beta-lactamases of Stenotrophomonas maltophilia. Antimicrobial Agents and Chemotherapy. 52:1198-1200. (Corresponding author)
  51. Su-Hua Huang, Tsuey-Ching Yang, Ming-Hong Tsai, I-ShouTasi, Huang-ChihLu, Pei-Hsin Chuang, Lei-Wan, Ying-Ju Lin, Chih-Ho Lai, and Cheng-Wen Lin. (2008) Gold nanoparticle-based RT-PCR and real-time quantitative RT-PCR assays for detection of Japanese encephalitis virus. Nanotechnology. 19:pp405101.
  52. Cheng-Wen Lin, Rouh-Mei Hu, Shao-Cheng Huang, Ying-Ju Hsiao, Tsuey-Ching Yang*. (2008) Induction potential of clavulanic acid toward L1 and L2 beta-lactamases of Stenotrophomonas maltophilia. European Journal of Clinical Microbiology & Infectious Disease 27:1273-1275. (Corresponding author)
  53. Rouh-Mei Hu, Kai-Hung Chiang, Cheng-Wen Lin, Tsuey-Ching Yang*. (2008) Modified nitrocefin-EDTA method to differentially quantify the induced L1 and L2 beta-lactamase in Stenotrophomonas maltophilia. Letters in Applied Microbiology 47:457-461. (Corresponding author)
  54. Cheng-Wen Lin, Chien-Shun Chiou, Yi-Chih Chang, Tsuey-Ching Yang*. (2008) Comparison of pulsed-field gel electrophoresis and three rep-PCR methods for evaluating the genetic relatedness of Stenotrophomonas maltophiliaisolates. Letters in Applied Microbiology 47:393-398. (Corresponding author)
  55. Cheng-Wen Lin*, Chieh-Wen Cheng, Tsuey-Ching Yang, Shih-Wein Li, Mei-Hsiu Cheng, Lei Wan, Ying-Ju Lin, Chih-Ho Lai, Wei-Yong Lin, Ming-Ching Kao. (2008) Interferon antagonist function of Japanese encephalitisvirus NS4A and its interaction with DEAD-box RNA helicase DDX42. Virus Research 137:49-55.
  56. Yi-Ming Hsiao, Mei-Huei Zheng, Rouh-Mei Hu, Tsuey-Ching Yang, Yi-Hsiung Tseng*. (2008) Regulation of pehA gene encoding the major polygalacturonase of Xanthomonas campestris by Clp and RpfF. Microbiology-SGM 154:705-713.
  57. Tsuey-Ching Yang, Rouh-Mei Hu, Shu-Fu Weng, and Yi-Hsiung Tseng*. (2007) Identification of a hypothetical protein of plant pathogenic Xanthomonas campestrisas a novel beta-galactosidase. Journal of Molecular Microbiology and Biotechnology 13:172-180.
  58. Lii-Tzu Wu, Shu-Ying Chang, Ming-Ren Yen, Tsuey-Ching Yang, Yi-Hsiung Tseng*. (2007) Characterization of extended-host-range pseudo-T-even bacteriophage Kpp95 isolated on Klebsiella pneumoniae. Applied and Environmental Microbiology 73:2532-2540.
  59. Rouh-Mei Hu, Tsuey-ChingYang, Shu-Hui Yang, Yi-Hsiung Tseng*. (2005) Deduction of upstream sequence of Xanthomonas campestris flagellar genes responding to transcription activation byFleQ. Biochemical and Biophysical Research Communications 335:1035-1043.
  60. Yi-Min Hsiao, Hsiu-Ying Liao, Mong-Chuan Lee, Tsuey-Ching Yang, Yi-Hsiung Tseng*. (2005) Clp upregulates transcription of engA gene encoding a virulence factor in Xanthomonas campestris by direct binding to the upstream tandem Clp sites. FEBS Letters 579:3525-3533.
  61. Tsuey-Ching Yang, Rouh-Mei Hu, Yi-Min Hsiao, Shu-Fen Weng, Yi-Hsiung Tseng*. (2003) Molecular genetic analyses of potential b-galactosidase genes in Xanthomonas campestris. Journal of Molecular Microbiology and Biotechnology 6:145-154. (First author)
  62. Tsuey-Ching Yang, Gong-Ho Wu, Yi-Hsiung Tseng*. (2002) Isolation of a Xanthomonas campestris strain with elevated b-galactosidase activity for direct use of lactose in xanthan gum production. Letters in Applied Microbiology 35:375-379.